Natamycin(95%) (523557)

Natamycin(95%) (523557)

• Natamycin (pimaricin) is a polyene macrolide antibiotic produced by submerged aerobic fermentation of Streptomycesnatalensis and related species. Fermentation is conducted for several days, and the antibiotic is isolated either by broth extraction or by extraction of the mycelium. The activity of natamycin against yeasts and moulds, but not bacteria, makes it convenient for use in foods that undergo a ripening period after processing. Its low solubility in water and most organic solvents makes it suitable for the surface treatment of foods.
  

  ITEM	DESCRIPTION
  Product Name	95% Natamycin
  Strain	Streptomycesnatalensis
  Appearance	White to creamy-white powder and odorless
  EU No.	E235
  Molecular Formula	C33H47NO13
  CAS	7681-93-8
  Solubility	Practically insoluble in water; slightly soluble in methanol; soluble in acetic acid and in dimethylformamide
  Stability	pH 3-9 Natamycin is relatively stable
  Moisture	8.0% Max.
  Assay(On dried basis)	More than 95.0%
  Sulphated ash	Not more than 0.5%
  Heavy Metals	Not more than 10mg/Kg
  Specific rotation	+250° – +295°
  Usage	The additive may be applied in cheese, meat food as a preservative
  pH	pH=5.5-7.5, 1% aqueous solution
  Total colony count	Mesophillic aerobic not more than 100 CFU/g
  Coliforms	25g Negative
  Listeria monocytogenes	25g Negative
  Storage	Natamycin is stable under room temperature. Sunlight, oxidant or heavy metal will hurt the activity of it. To be stored in dry, shady and cool place(below 20°C) with sealed packing
  Shelf life	24 months

• Its medical use is now confined to topical treatment of corneal fungal infections and the prevention of such infections in users of contact lens. Natamycin is used topically in veterinary medicine to treat mycotic infections, such as ringworm in cattle and horses. Previously, it was used topically against fungal infections of the skin and mucous membranes in humans.